Nanomaterials - Quantification of nano-object release from powders by generation of aerosols (ISO/TS 12025:2021)

This technical specification establishes a structured methodology for the quantitative determination of nanoparticle release during aerosol manufacturing processes. As nanotechnology expands across various industrial sectors, ensuring safety and environmental compliance requires precise measurement techniques. This document addresses the specific challenge of quantifying particles generated when materials are processed in airborne states. It outlines standardized protocols for sampling, analysis, and data reporting to support consistent evaluation of potential exposures. The approach focuses on characterizing the release fractions of nanoparticles, enabling industries to assess and manage related risks effectively. By providing a unified framework, it facilitates comparison of data across different facilities and experimental setups. The guidance covers critical parameters such as detection limits, sampling strategies, and calculation methods tailored to aerosolized nanomaterials. This ensures that measurements are reliable and reproducible, supporting regulatory compliance and internal safety assessments. It serves as a practical tool for laboratories and manufacturers seeking to implement robust monitoring systems for nanoparticle emissions during production.